Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.66 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.41 |
| ▸ | MTOR | P42345 | 11/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23781559 | 0.81 | CYP2C19 (0.96) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL10398852 | 0.79 | CYP1A2 (0.58) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL10398851 | 0.79 | CYP1A2 (0.58) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL10398854 | 0.79 | CYP1A2 (0.58) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL23781601 | 0.78 | CYP2A6 (0.57) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL6179282 | 0.77 | ALDH1A1 (0.47) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL28420710 | 0.77 | ALDH1A1 (0.47) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL6132989 | 0.77 | GRM5 (0.50) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL20469398 | 0.77 | ALDH1A1 (0.44) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 | |
| SCHEMBL31044583 | 0.77 | GRM5 (0.50) | CYP2A6CYP2B6CYP2C19CYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10246429-B2 | Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use | AMGEN INC. (US) | 2019-04-02 | — | — | US | disclosed |
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2018-08-09 | — | — | US | disclosed |
| WO-2009153536-A1 | 1-AZA-BICYCLO [2.2.2] OCTANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | BACE1, BACE2, APP | CYP2A6 759/4885CYP2B6 745/4885CYP2C19 1401/4885 |
| US-10246429-B2 | Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use | BACE1, BACE2, APP | CYP2A6 759/4885CYP2B6 745/4885CYP2C19 1401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.