Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281884 | 0.87 | CHRM2 (0.36) | CYP4F2CYP4A11CHRM2CHRM1CHRM3 | |
| SCHEMBL4272644 | 0.86 | CYP4F2 (0.45) | CYP4F2CYP4A11LMNAKDM4ECYP3A4 | |
| SCHEMBL4274299 | 0.80 | TDP1 (0.47) | KDM4E | |
| SCHEMBL3179219 | 0.80 | TDP1 (0.47) | KDM4E | |
| SCHEMBL3174338 | 0.79 | TSHR (0.48) | LMNA | |
| SCHEMBL4276832 | 0.79 | CYP4F2 (0.37) | CYP4F2CYP4A11LMNAKDM4ECYP3A4 | |
| SCHEMBL23203397 | 0.78 | LMNA (0.48) | LMNAKDM4ECYP3A4ALOX5 | |
| SCHEMBL18745359 | 0.76 | LMNA (0.50) | LMNAALOX5CHRM2CHRM1 | |
| SCHEMBL3178954 | 0.75 | BRD4 (0.49) | CYP4F2CYP4A11 | |
| SCHEMBL4275713 | 0.75 | CYP4F2 (0.66) | CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |