Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 10/20 | 0.69 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.69 |
| ▸ | ADCY10 | Q96PN6 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718236 | 0.82 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1ADCY10KDM4EMAOB | |
| SCHEMBL13880333 | 0.79 | AGPAT2 (0.64) | CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3950560 | 0.76 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1ADCY10KDM4EKMT2A | |
| SCHEMBL30507528 | 0.76 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1KDM4EMAOBNCOA1 | |
| SCHEMBL28501185 | 0.76 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1KDM4EMAOBNCOA1 | |
| SCHEMBL3394031 | 0.75 | NCOA1 (0.44) | HSP90AA1HSP90AB1MAOBNCOA1NCOA3 | |
| SCHEMBL16441869 | 0.74 | MEN1 (0.75) | HSP90AA1HSP90AB1ADCY10KDM4EMEN1 | |
| SCHEMBL3952031 | 0.73 | HSP90AA1 (0.78) | HSP90AA1HSP90AB1ADCY10KDM4E | |
| SCHEMBL28505487 | 0.73 | ACHE (0.55) | HSP90AA1KDM4EMEN1KMT2ANCOA1 | |
| SCHEMBL3952089 | 0.73 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1ADCY10KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | CELL THERAPEUTICS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-7419984-B2 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-20040204386-A1 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204386-A1 | Pyrimidines and uses thereof | LPCAT3, LPCAT1, APRT | HSP90AA1 4126/4885HSP90AB1 4236/4885ADCY10 1194/4885 |
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | LPCAT3, LPCAT1, APRT | HSP90AA1 4006/4885HSP90AB1 3829/4885ADCY10 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.