Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PLTP | P55058 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4287316 | 0.99 | HPGD (0.52) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4276192 | 0.91 | HPGD (0.58) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4275912 | 0.90 | SMN1; SMN2 (0.51) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4287252 | 0.90 | HPGD (0.57) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4275235 | 0.89 | SMN1; SMN2 (0.51) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4274873 | 0.89 | SMN1; SMN2 (0.48) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4283504 | 0.88 | HPGD (0.47) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4279972 | 0.88 | SMN1; SMN2 (0.47) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4288907 | 0.87 | HPGD (0.52) | HPGDSMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4275856 | 0.87 | SCD (0.47) | HPGDSMN1; SMN2LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | claimed |
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |