Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.56 |
| ▸ | FABP1 | P07148 | 2/20 | 0.53 |
| ▸ | FABP4 | P15090 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283030 | 0.85 | NR1H4 (0.66) | NR1H4FABP1 | |
| SCHEMBL4284357 | 0.84 | NR1H4 (0.55) | NR1H4FABP1 | |
| SCHEMBL2128869 | 0.82 | NR1H4 (0.62) | NR1H4 | |
| SCHEMBL19627400 | 0.81 | NR1H4 (0.68) | NR1H4 | |
| SCHEMBL12168805 | 0.78 | NR1H4 (0.74) | NR1H4FABP1 | |
| SCHEMBL19628515 | 0.78 | NR1H4 (0.59) | NR1H4FABP1FABP4 | |
| SCHEMBL19629748 | 0.78 | NR1H4 (0.54) | NR1H4 | |
| SCHEMBL29467359 | 0.78 | NR1H4 (0.53) | NR1H4FABP1 | |
| SCHEMBL28728433 | 0.78 | NR1H4 (0.53) | NR1H4FABP1 | |
| SCHEMBL19629742 | 0.78 | NR1H4 (0.64) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009149795-A2 | HETEROCYCLIC CYCLOPROPYL-SUBSTITUTED FXR BINDING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2009-12-17 | — | — | WO | disclosed |
| EP-2128158-A1 | Heterocyclic cyclopropyl-substituted FXR binding compounds | Phenex Pharmaceuticals AG (DE) | 2009-12-02 | — | — | EP | disclosed |