Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 8/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30950724 | 0.84 | ALDH1A1 (0.50) | EPHX2MAPK14ALDH1A1CNR2CNR1 | |
| SCHEMBL8764313 | 0.83 | EPHX2 (0.53) | EPHX2MAPK14ALDH1A1IDO1CNR2 | |
| SCHEMBL5031598 | 0.83 | ALDH1A1 (0.69) | MAPK14ALDH1A1CNR2CNR1CYP2C8 | |
| SCHEMBL9891929 | 0.80 | EPHX2 (0.51) | EPHX2MAPK14ALDH1A1IDO1CNR2 | |
| SCHEMBL9891522 | 0.80 | ALDH1A1 (0.53) | EPHX2MAPK14ALDH1A1IDO1CNR2 | |
| SCHEMBL9892898 | 0.79 | EPHX2 (0.50) | EPHX2MAPK14ALDH1A1IDO1CNR2 | |
| SCHEMBL30486167 | 0.78 | CNR2 (0.54) | MAPK14ALDH1A1CNR2CNR1RPS6KA2 | |
| SCHEMBL18884374 | 0.76 | EPHX2 (0.42) | EPHX2MAPK14ALDH1A1IDO1CNR2 | |
| SCHEMBL5067070 | 0.74 | EPHX2 (0.46) | EPHX2MAPK14ALDH1A1IDO1CNR2 | |
| SCHEMBL10719716 | 0.74 | EPHX2 (0.52) | EPHX2MAPK14ALDH1A1IDO1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063897-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008034008-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2008-03-20 | — | — | WO | claimed |