Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 15/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.41 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2887759 | 0.92 | KCNA5 (0.44) | KCNA5KCNH2CYP3A4CYP2C9MEN1 | |
| SCHEMBL2882170 | 0.92 | CYP3A4 (0.45) | KCNA5KCNH2CYP3A4CYP2C9MEN1 | |
| SCHEMBL2885045 | 0.90 | KCNA5 (0.42) | KCNA5KCNH2CYP3A4CYP2C9MEN1 | |
| SCHEMBL4502188 | 0.80 | CYP3A4 (0.42) | KCNA5KCNH2CYP3A4CYP2C9MEN1 | |
| SCHEMBL2884875 | 0.79 | KCNA5 (0.53) | KCNA5KCNH2CYP3A4CYP2C9MEN1 | |
| SCHEMBL4284478 | 0.79 | KCNA5 (0.41) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL2884885 | 0.72 | KCNA5 (0.59) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL2885945 | 0.72 | KCNA5 (0.57) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL2882049 | 0.71 | KCNA5 (0.59) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL2879884 | 0.71 | KCNA5 (0.62) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | claimed |