SCHEMBL4284868

SCHEMBL4284868

C[C@H]([NH])C[NH]

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL989219 1.00
SCHEMBL43408 0.74
SCHEMBL42216 0.70
SCHEMBL10002814 0.70
SCHEMBL4990386 0.70
SCHEMBL987995 0.70
SCHEMBL2427328 0.70
SCHEMBL749824 0.67
SCHEMBL1767137 0.67
Hydrochloric Acid SCHEMBL10488738 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050101525-A1 METHOD OF COMPLEXING A NUCLEIC ACID WITH A LIPID-CONJUGATED POLYAMIDE ZUCKERMANN RONALD N (US) 2005-05-12 US claimed
EP-1003558-B1 LIPID-POLYAMIDE CONJUGATES AND COMPOSITIONS FOR NUCLEIC ACID DELIVERY CHIRON CORP (US) 2004-03-17 EP claimed
US-20040018962-A1 Lipid-conjugated polyamide compounds CHIRON CORPORATION 2004-01-29 US claimed
US-6572881-B1 Delivery of polynucleotides to cells; polylactam CHIRON CORPORATION 2003-06-03 US claimed
US-6569450-B1 For facilitating the delivery of polynucleotides to cells CHIRON CORPORATION 2003-05-27 US claimed
US-6197332-B1 ACYLATION AND AMIDATION TO FORM POLYAMIDES FOR CONJUGATED LIPIDS CHIRON CORPORATION 2001-03-06 US claimed
US-20150031743-A1 CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA, RELATED COMPOSITIONS AND METHODS OF MAKING AND USE NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2015-01-29 US disclosed
US-8772255-B2 Cell transfecting formulations of small interfering RNA related compositions and methods of making and use NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2014-07-08 US disclosed
EP-1709195-B1 CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA, RELATED COMPOSITIONS AND METHODS OF MAKING AND USE NOVARTIS VACCINES & DIAGNOSTIC (US) 2014-01-22 EP disclosed
US-20090143322-A1 CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA RELATED COMPOSITIONS AND METHODS OF MAKING AND USE CHIRON CORPORATION (US) 2009-06-04 US disclosed
US-7214384-B2 Lipid-conjugated polyamide compounds NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2007-05-08 US disclosed
EP-1709195-A2 CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA, RELATED COMPOSITIONS AND METHODS OF MAKING AND USE CHIRON CORPORATION (US) 2006-10-11 EP disclosed
US-20060019912-A1 Cell transfecting formulations of small interfering RNA related compositions and methods of making and use CHIRON CORPORATION 2006-01-26 US disclosed
WO-2005060697-A2 CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA, RELATED COMPOSITIONS AND METHODS OF MAKING AND USE CHIRON CORPORATION (US) 2005-07-07 WO disclosed
US-20050101525-A1 METHOD OF COMPLEXING A NUCLEIC ACID WITH A LIPID-CONJUGATED POLYAMIDE ZUCKERMANN RONALD N (US) 2005-05-12 US disclosed
EP-1003558-B1 LIPID-POLYAMIDE CONJUGATES AND COMPOSITIONS FOR NUCLEIC ACID DELIVERY CHIRON CORP (US) 2004-03-17 EP disclosed
US-20040018962-A1 Lipid-conjugated polyamide compounds CHIRON CORPORATION 2004-01-29 US disclosed
US-6572881-B1 Delivery of polynucleotides to cells; polylactam CHIRON CORPORATION 2003-06-03 US disclosed
US-6569450-B1 For facilitating the delivery of polynucleotides to cells CHIRON CORPORATION 2003-05-27 US disclosed
US-6197332-B1 ACYLATION AND AMIDATION TO FORM POLYAMIDES FOR CONJUGATED LIPIDS CHIRON CORPORATION 2001-03-06 US disclosed