Vindesine

Vindesine

SCHEMBL4285

CC[C@]1(O)C[C@H]2C[N@](CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1.O=S(=O)(O)O

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Vindesine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A known ✓ P04350 12/20 0.85
TUBB known ✓ P07437 12/20 0.85
TUBA3C known ✓ P0DPH7 12/20 0.85
TUBA1B known ✓ P68363 12/20 0.85
TUBA4A known ✓ P68366 12/20 0.85
TUBB4B known ✓ P68371 12/20 0.85
TUBB3 known ✓ Q13509 12/20 0.85
TUBB2A known ✓ Q13885 12/20 0.85
TUBB8 known ✓ Q3ZCM7 12/20 0.85
TUBA3E known ✓ Q6PEY2 12/20 0.85
TUBA1A known ✓ Q71U36 12/20 0.85
TUBA1C known ✓ Q9BQE3 12/20 0.85
TUBB6 known ✓ Q9BUF5 12/20 0.85
TUBB2B known ✓ Q9BVA1 12/20 0.85
TUBB1 known ✓ Q9H4B7 12/20 0.85
MLNR O43193 1/20 0.96
PTGS2 P35354 1/20 0.96
KCNH2 Q12809 1/20 0.96
GHSR Q92847 1/20 0.96
MAPT P10636 5/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Vindesine SCHEMBL1650601 1.00 MLNR (0.96) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL28250735 1.00 MLNR (0.96) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL28177485 1.00 MLNR (0.96) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL29370847 1.00 MLNR (0.96) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL29895728 1.00 MLNR (0.96) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL28186617 1.00 MLNR (0.96) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL11481610 0.99 MLNR (0.95) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL28212242 0.99 MLNR (0.95) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL16553307 0.99 MLNR (0.95) MLNRPTGS2KCNH2GHSRTUBB4A
Vindesine SCHEMBL15866615 0.98 MLNR (1.00) MLNRPTGS2KCNH2GHSRTUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 22428 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-20260034101-A1 ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS FROST BIOLOGIC INC (US) 2026-02-05 US claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
EP-4637751-A2 FOXM1 INHIBITORS AND THEIR USE IN TREATING CANCERS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2025-10-29 EP claimed
US-12383533-B2 Antimitotic amides for the treatment of cancer and proliferative disorders FROST BIOLOGIC, INC. (US) 2025-08-12 US claimed
WO-2025151443-A1 ENDOXIFEN FOR TREATMENT OF RARE CANCERS ATOSSA THERAPEUTICS, INC. (US) 2025-07-17 WO claimed
US-12325755-B2 Macropinocytosing human anti-CD46 antibodies and targeted cancer therapeutics THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-06-10 US claimed
WO-2025087695-A1 METHOD FOR PRODUCING RECOMBINANT ADENO-ASSOCIATED VIRUS PARTICLES ASCEND ADVANCED THERAPIES LTD (GB) 2025-05-01 WO claimed
US-12257251-B2 Use of FAK inhibitor in preparation of drug for treating tumors having NRAS mutation INXMED (NANJING) CO., LTD. (CN) 2025-03-25 US claimed
EP-4524131-A1 SMALL MOLECULES FOR TREATING CANCER, INHABITING CHEMOKINE ACTIVITY AND/OR INDUCING CELL DEATH AlonBio Ltd. (IL) 2025-03-19 EP claimed
WO-1999001118-A9 ANTIOXIDANT ENHANCEMENT OF THERAPY FOR HYPERPROLIFERATIVE CONDITIONS ATHEROGENICS INC (US) 1999-05-20 WO claimed
EP-0912738-A2 ANTIGEN BINDING FRAGMENTS THAT SPECIFICALLY DETECT CANCER CELLS, NUCLEOTIDES ENCODING THE FRAGMENTS, AND USE THEREOF FOR THE PROPHYLAXIS AND DETECTION OF CANCERS Novopharm Biotech, Inc. (CA) 1999-05-06 EP claimed
WO-1999001118-A2 ANTIOXIDANT ENHANCEMENT OF THERAPY FOR HYPERPROLIFERATIVE CONDITIONS ATHEROGENICS, INC. (US) 1999-01-14 WO claimed
EP-0875246-A1 Pharmaceutical preparation of ascorbic acid derivatives for medical treatment of cancer SHOWA DENKO KABUSHIKI KAISHA (JP) 1998-11-04 EP claimed
WO-1998040088-A1 COMPOSITIONS FOR TREATING TUMORS CONTAINING SHARK CARTILAGE EXTRACTS AND ANTI-NEOPLASTIC AGENTS LES LABORATOIRES AETERNA INC. (CA) 1998-09-17 WO claimed
WO-1997044461-A2 ANTIGEN BINDING FRAGMENTS THAT SPECIFICALLY DETECT CANCER CELLS, NUCLEOTIDES ENCODING THE FRAGMENTS, AND USE THEREOF FOR THE PROPHYLAXIS AND DETECTION OF CANCERS NOVOPHARM BIOTECH, INC. (CA) 1997-11-27 WO claimed
EP-0608546-A2 Glia activating factor (GAF), antibodies against it and their uses TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-08-03 EP claimed
EP-0120907-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY Aston Molecules Limited (GB) 1984-10-10 EP claimed
WO-1984001506-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY UNIV BIRMINGHAM (GB) 1984-04-26 WO claimed
EP-0009996-A1 Preparation of vindesine monosulfate ELI LILLY AND COMPANY (US) 1980-04-16 EP claimed