Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 7/20 | 0.42 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4280068 | 0.98 | IDO1 (0.50) | IDO1MAP4K4JAK2AGPAT2CYP1A2 | |
| SCHEMBL15328998 | 0.84 | CYP1A2 (0.42) | IDO1MAP4K4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16068170 | 0.78 | AGPAT2 (0.44) | IDO1MAP4K4JAK2AGPAT2CYP1A2 | |
| SCHEMBL39774 | 0.77 | IDO1 (0.50) | IDO1MAP4K4JAK2CLK4ALOX15 | |
| SCHEMBL25983832 | 0.75 | ALDH1A1 (0.47) | HSD17B10ALOX15CYP3A4ALDH1A1TSHR | |
| SCHEMBL4277914 | 0.74 | AGPAT2 (0.50) | IDO1MAP4K4JAK2AGPAT2CDK7 | |
| SCHEMBL28267174 | 0.73 | CDC7 (0.38) | IDO1MAP4K4JAK2CYP1A2CYP2D6 | |
| SCHEMBL4278314 | 0.73 | AGPAT2 (0.65) | AGPAT2CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL20383160 | 0.72 | CYP3A4 (0.56) | IDO1MAP4K4JAK2AGPAT2CYP3A4 | |
| SCHEMBL11627415 | 0.71 | IDO1 (0.56) | IDO1MAP4K4JAK2AGPAT2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | CELL THERAPEUTICS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-7419984-B2 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-20040204386-A1 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204386-A1 | Pyrimidines and uses thereof | LPCAT3, LPCAT1, APRT | IDO1 1564/4885MAP4K4 2677/4885JAK2 2740/4885 |
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | LPCAT3, LPCAT1, APRT | IDO1 1550/4885MAP4K4 2926/4885JAK2 2827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.