SCHEMBL4285685

SCHEMBL4285685

CCOC(=O)c1cc(O)c(C(=O)c2ccc(OC3CC3)cc2)c(F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 3/20 0.50
CA12 O43570 3/20 0.48
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
CA7 P43166 3/20 0.48
CA9 Q16790 3/20 0.48
CA14 Q9ULX7 3/20 0.48
PTPN11 Q06124 1/20 0.43
ESR1 P03372 2/20 0.41
ESR2 Q92731 1/20 0.41
HSD17B2 P37059 1/20 0.41
STS P08842 1/20 0.41
PARP10 Q53GL7 1/20 0.41
GRIN1 Q05586 2/20 0.41
GRIN2B Q13224 2/20 0.41
LMNA P02545 2/20 0.40
MAOA P21397 2/20 0.40
NR1H2 P55055 1/20 0.40
NR1H3 Q13133 1/20 0.40
CYP1A2 P05177 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4294425 0.89 EPHX2 (0.51) EPHX2CA12CA1CA2CA7
SCHEMBL4282977 0.85 CA12 (0.55) CA12CA1CA2CA7CA9
SCHEMBL4293669 0.84 CA12 (0.49) CA12CA1CA2CA7CA9
SCHEMBL4284949 0.84 CA12 (0.54) CA12CA1CA2CA7CA9
SCHEMBL4293132 0.83 PTPN11 (0.43) EPHX2CA12CA1CA2CA7
SCHEMBL11756971 0.80 LMNA (0.61) EPHX2CA12CA1CA2CA7
SCHEMBL11758763 0.76 PARP10 (0.59) EPHX2CA12CA1CA2CA7
SCHEMBL3040308 0.76 NR1H2 (0.44) EPHX2CA12CA1CA2CA7
SCHEMBL3910337 0.75 SCN1A (0.58) EPHX2CA12CA1CA2CA7
SCHEMBL4279703 0.74 CA12 (0.43) EPHX2CA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 EPHX2 4388/4885CA12 2069/4885CA1 2477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.