Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4552798 | 0.88 | CHRM2 (0.44) | CHRM2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10044461 | 0.87 | CHRM2 (0.56) | CHRM2PAOXMAOAMAOBNFKB1 | |
| SCHEMBL3293010 | 0.85 | CHRM2 (0.43) | CHRM2DDB1CRBNGGPS1FDPS | |
| SCHEMBL10044468 | 0.85 | CHRM2 (0.60) | CHRM2PAOXMAOAMAOBNFKB1 | |
| SCHEMBL13573476 | 0.85 | CHRM2 (0.60) | CHRM2PAOXMAOAMAOBNFKB1 | |
| SCHEMBL21320204 | 0.84 | — | — | |
| SCHEMBL24112603 | 0.83 | CHRM2 (0.56) | CHRM2PAOXNFKB1CYP2D6BLM | |
| SCHEMBL8381419 | 0.83 | GGPS1 (0.46) | KMT2AMEN1KDM4ACYP1A2GGPS1 | |
| SCHEMBL7348316 | 0.81 | S1PR2 (0.48) | KMT2AMEN1KDM4ACYP1A2GGPS1 | |
| SCHEMBL16562360 | 0.81 | S1PR2 (0.48) | KMT2AMEN1KDM4ACYP1A2GGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300010-B1 | PYRAZINE DERIVATIVES AS EPITHELIAL SODIUM CHANNEL BLOCKERS | NOVARTIS AG (CH) | 2015-03-04 | — | — | EP | disclosed |
| US-8236808-B2 | Pyrazine derivatives as ENAC blockers | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | disclosed |
| WO-2009150137-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-12-17 | — | — | WO | disclosed |