Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13705446 | 0.95 | HCRTR1 (0.36) | HCRTR1HCRTR2OPRM1OPRK1 | |
| SCHEMBL4295398 | 0.87 | HCRTR1 (0.42) | HCRTR1HCRTR2OPRK1KDM4EALDH1A1 | |
| SCHEMBL4288806 | 0.87 | HCRTR1 (0.39) | HCRTR1HCRTR2KDM4EALDH1A1 | |
| SCHEMBL4282750 | 0.87 | HCRTR1 (0.37) | HCRTR1HCRTR2KDM4EALDH1A1TDP1 | |
| SCHEMBL4293415 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL4281702 | 0.86 | HCRTR1 (0.41) | HCRTR1HCRTR2KDM4EALDH1A1 | |
| SCHEMBL4295796 | 0.85 | HCRTR2 (0.40) | HCRTR1HCRTR2OPRK1 | |
| SCHEMBL4292999 | 0.84 | HCRTR1 (0.45) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL4287718 | 0.83 | HCRTR1 (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL4281285 | 0.83 | HCRTR1 (0.43) | HCRTR1HCRTR2KDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | HCRTR1 3147/4885HCRTR2 3136/4885OPRM1 3919/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | HCRTR1 3147/4885HCRTR2 3136/4885OPRM1 3919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.