Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128299 | 0.86 | TP53 (0.49) | NOTUMCYP2C9S1PR1TSHRKMT2A | |
| SCHEMBL3456314 | 0.83 | TP53 (0.51) | NOTUMTSHRKMT2ASMN1; SMN2HPGD | |
| SCHEMBL4284878 | 0.82 | NOTUM (0.49) | NOTUMCYP2C9S1PR1TSHRKMT2A | |
| SCHEMBL7814158 | 0.81 | NOTUM (0.65) | NOTUMCYP2C9TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL20908660 | 0.81 | NOTUM (0.65) | NOTUMCYP2C9S1PR1TSHRKMT2A | |
| SCHEMBL3457235 | 0.79 | NOTUM (0.65) | NOTUMKMT2ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL21425395 | 0.79 | CYP11B1 (0.48) | NOTUMTDP1TP53MAPT | |
| SCHEMBL20941553 | 0.77 | TP53 (0.51) | KMT2AMEN1POLBALDH1A1HSD17B10 | |
| SCHEMBL2278917 | 0.77 | NOTUM (1.00) | NOTUMTSHRKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL31650229 | 0.77 | NOTUM (1.00) | NOTUMTSHRKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151621-A1 | SUBSTITUTED (1, 2, 4-0XADIAZ0L-3-YL) INDOLIN-1-YL CARBOXYLIC ACID DERIVATIVES USEFUL AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |