Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13656966 | 0.83 | GPR119 (0.47) | NOTUMTP53GPR119DRD2CYP11B1 | |
| SCHEMBL4286559 | 0.82 | NOTUM (0.62) | NOTUMTP53TSHRALDH1A1S1PR1 | |
| SCHEMBL3128299 | 0.79 | TP53 (0.49) | NOTUMTP53TSHRUSP2ALDH1A1 | |
| SCHEMBL4279462 | 0.78 | NOTUM (0.46) | NOTUMTP53GPR119TSHRUSP2 | |
| SCHEMBL3456314 | 0.76 | TP53 (0.51) | NOTUMTP53TSHRUSP2ALDH1A1 | |
| SCHEMBL773073 | 0.76 | DRD2 (0.64) | ALDH1A1S1PR1DRD2MEN1MAPT | |
| SCHEMBL3457235 | 0.75 | NOTUM (0.65) | NOTUMTP53ALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL4284699 | 0.73 | FNTA (0.41) | GPR119DRD2 | |
| SCHEMBL21425395 | 0.72 | CYP11B1 (0.48) | NOTUMTP53CYP11B1CYP11B2MAPT | |
| SCHEMBL3129984 | 0.71 | CA12 (0.60) | NOTUMTP53S1PR1S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151621-A1 | SUBSTITUTED (1, 2, 4-0XADIAZ0L-3-YL) INDOLIN-1-YL CARBOXYLIC ACID DERIVATIVES USEFUL AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |