Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 4/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.54 |
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.45 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285440 | 0.79 | OGA (0.53) | CLK2LRRK2ACHE | |
| SCHEMBL29757925 | 0.79 | ACHE (0.49) | CLK2LRRK2ACHE | |
| SCHEMBL10196668 | 0.78 | MAPK7 (0.52) | CLK2LRRK2NAMPTMAPK8MAPK9 | |
| SCHEMBL27229190 | 0.78 | CLK2 (0.53) | CLK2LRRK2NAMPTMAPK8MAPK9 | |
| SCHEMBL28694743 | 0.77 | MAPK8 (0.54) | CLK2LRRK2MAPK8MAPK9MAPK10 | |
| SCHEMBL6966254 | 0.77 | EGFR (0.70) | NAMPTMAPK8MAPK10BCAT2EGFR | |
| SCHEMBL27229309 | 0.76 | CLK2 (0.69) | CLK2LRRK2NAMPTMAPK8MAPK9 | |
| SCHEMBL10196675 | 0.76 | MAPK7 (0.56) | CLK2LRRK2NAMPTMAPK8MAPK9 | |
| SCHEMBL10194839 | 0.76 | MAPK7 (0.56) | CLK2LRRK2NAMPTMAPK7 | |
| SCHEMBL28694761 | 0.76 | SMN1; SMN2 (0.53) | CLK2LRRK2MAPK7ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | GSK3B, GSK3A, GSKIP | CLK2 2982/4885LRRK2 828/4885NAMPT 954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.