SCHEMBL4286857

SCHEMBL4286857

CC(=O)[C@](N)(Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ HIF1A Q16665 1/20 0.35
▸ BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL894472 1.00 SMN1; SMN2 (0.35) SMN1; SMN2HIF1ABLM
Water SCHEMBL8680777 0.98 SMN1; SMN2 (0.34) SMN1; SMN2HIF1ABLM
SCHEMBL19065141 0.82 SMN1; SMN2 (0.32) SMN1; SMN2HIF1A
SCHEMBL9717846 0.82 SMN1; SMN2 (0.32) SMN1; SMN2HIF1A
SCHEMBL19065143 0.82 SMN1; SMN2 (0.32) SMN1; SMN2HIF1A
SCHEMBL26092373 0.81 BLM (0.31) SMN1; SMN2HIF1ABLM
SCHEMBL59405 0.81 BLM (0.47) SMN1; SMN2HIF1ABLM
SCHEMBL163221 0.81 BLM (0.47) SMN1; SMN2HIF1ABLM
SCHEMBL59406 0.81 BLM (0.47) SMN1; SMN2HIF1ABLM
SCHEMBL13702468 0.81 BLM (0.33) BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107205948-B Tablets comprising a GLP-1 agonist and an enteric coating 诺和诺德股份有限公司 2021-12-14 — — CN claimed
CN-107205948-A Tablets comprising a GLP-1 agonist and an enteric coating 诺和诺德股份有限公司 2017-09-26 — — CN claimed
CN-105154498-A Semi-recombinant preparation of GLP-1 analogues NOVO NORDISK AS 2015-12-16 — — CN claimed
CN-101842109-A Peptides derivatized with A-B-C-D- and their therapeutical use NOVO NORDISK AS 2010-09-22 — — CN claimed
CN-115925994-A Polypeptide Conjugates and Methods of Use 北京质肽生物医药科技有限公司 2023-04-07 — — CN disclosed
CN-115925995-A Polypeptide Conjugates and Methods of Use 北京质肽生物医药科技有限公司 2023-04-07 — — CN disclosed
CN-114729060-B Polypeptide conjugates and methods of use 北京质肽生物医药科技有限公司 2022-11-25 — — CN disclosed
CN-115260313-A Fusion proteins of GLP-1 and GDF15 and conjugates thereof 北京质肽生物医药科技有限公司 2022-11-01 — — CN disclosed
CN-107205948-B Tablets comprising a GLP-1 agonist and an enteric coating 诺和诺德股份有限公司 2021-12-14 — — CN disclosed
CN-106008569-B9 Borate as arginase inhibitor and composition and application thereof 马尔斯公司 2020-05-22 — — CN disclosed
CN-106008569-B Borate as arginase inhibitor and composition and application thereof 马尔斯公司 2020-04-03 — — CN disclosed
CN-110769846-A Solid composition for oral administration 诺和诺德股份有限公司 2020-02-07 — — CN disclosed
WO-2013148966-A1 TRANSMUCOSAL DELIVERY OF ENGINEERED POLYPEPTIDES AMYLIN PHARMACEUTICALS, LLC (US) 2013-10-03 — — WO disclosed
WO-2013009545-A1 ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION WITH REDUCED IMMUNOGENICITY AMYLIN PHARMACEUTICALS, INC. (US) 2013-01-17 — — WO disclosed
CN-102361647-A Fgf21 derivatives with albumin binder a-b-c-d-e- and their use NOVO NORDISK AS 2012-02-22 — — CN disclosed
CN-101868476-A Glucagon-like peptide-1 derivatives and their pharmaceutical use NOVO NORDISK AS 2010-10-20 — — CN disclosed
CN-101842109-A Peptides derivatized with A-B-C-D- and their therapeutical use NOVO NORDISK AS 2010-09-22 — — CN disclosed
EP-2118131-A1 GLUCAGON-LIKE PROTEIN-1 RECEPTOR (GLP-1R) AGONIST COMPOUNDS CovX Technologies Ireland Limited (IE) 2009-11-18 — — EP disclosed
US-20090098130-A1 GLUCAGON-LIKE PROTEIN-1 RECEPTOR (GLP-1R) AGONIST COMPOUNDS COVX TECHNOLOGIES IRELAND LIMITED (IE) 2009-04-16 — — US disclosed
WO-2008081418-A1 GLUCAGON-LIKE PROTEIN-1 RECEPTOR (GLP-1R) AGONIST COMPOUNDS COVX TECHNOLOGIES IRELAND LIMITED (IE) 2008-07-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090098130-A1 GLUCAGON-LIKE PROTEIN-1 RECEPTOR (GLP-1R) AGONIST COMPOUNDS GLP1R, GIPR, GCGR SMN1; SMN2 3888/4885HIF1A 1106/4885BLM 4451/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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