Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 12/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RGS12 | O14924 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1944947 | 0.78 | ADORA2B (0.74) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1948516 | 0.78 | ADORA2B (0.73) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1943878 | 0.72 | ADORA2B (0.72) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4293285 | 0.71 | BRD4 (0.39) | L3MBTL1CCR2 | |
| SCHEMBL5687959 | 0.70 | ADORA2B (0.63) | ADORA2BADORA1ADORA2AADORA3ALDH1A1 | |
| SCHEMBL4016371 | 0.70 | ADORA2B (0.64) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1945854 | 0.70 | ADORA2B (0.58) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL4021124 | 0.69 | AKT2 (0.38) | ADORA2BADORA2AALDH1A1KDM4EMEN1 | |
| SCHEMBL2328375 | 0.68 | ADORA2B (0.71) | ADORA2BADORA1ADORA2AADORA3 | |
| SCHEMBL1947269 | 0.68 | ADORA2B (0.69) | ADORA2BADORA1ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009157938-A1 | A2B ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING CANCER | CV THERAPEUTICS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |