Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.44 |
| ▸ | STAT6 | P42226 | 3/20 | 0.43 |
| ▸ | CDK4 | P11802 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 8/20 | 0.42 |
| ▸ | BRD4 | O60885 | 8/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | BRD2 | P25440 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287761 | 1.00 | FGFR4 (0.45) | FGFR4FGFR1FGFR2FGFR3RPS6KA3 | |
| SCHEMBL3402022 | 0.86 | FGFR1 (0.46) | FGFR4FGFR1FGFR2FGFR3RPS6KA3 | |
| SCHEMBL22511944 | 0.84 | JAK2 (0.46) | FGFR4FGFR1FGFR2FGFR3RPS6KA3 | |
| SCHEMBL1655083 | 0.83 | RPS6KA3 (0.49) | FGFR4FGFR1FGFR2FGFR3RPS6KA3 | |
| SCHEMBL1655086 | 0.83 | RPS6KA3 (0.49) | FGFR4FGFR1FGFR2FGFR3RPS6KA3 | |
| SCHEMBL1657589 | 0.83 | JAK2 (0.51) | FGFR4FGFR1FGFR2FGFR3CDK4 | |
| SCHEMBL4290022 | 0.83 | AURKA (0.51) | FGFR4FGFR1FGFR2FGFR3RPS6KA3 | |
| SCHEMBL1657593 | 0.83 | JAK2 (0.51) | FGFR4FGFR1FGFR2FGFR3CDK4 | |
| SCHEMBL4290025 | 0.83 | AURKA (0.51) | FGFR4FGFR1FGFR2FGFR3RPS6KA3 | |
| SCHEMBL3402015 | 0.82 | PTK2 (0.46) | FGFR4FGFR1FGFR2FGFR3RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | claimed |
| US-8420657-B2 | Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2013-04-16 | — | — | US | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | FGFR4 660/4885FGFR1 148/4885FGFR2 371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.