Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.67 |
| ▸ | GSK3B | P49841 | 4/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.65 |
| ▸ | CLK2 | P49760 | 5/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.65 |
| ▸ | PRKACA | P17612 | 3/20 | 0.65 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.65 |
| ▸ | PRKX | P51817 | 2/20 | 0.65 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.65 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.65 |
| ▸ | FLT3 | P36888 | 2/20 | 0.65 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | PRKCG | P05129 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | AKT1 | P31749 | 1/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.65 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4288050 | 0.87 | ROCK2 (0.57) | ROCK2GSK3BDYRK1ACLK2CLK4 | |
| SCHEMBL3639415 | 0.80 | ROCK2 (1.00) | ROCK2GSK3BDYRK1ACLK2CLK4 | |
| SCHEMBL4286537 | 0.79 | CLK4 (1.00) | ROCK2GSK3BDYRK1ACLK2CLK4 | |
| SCHEMBL24137561 | 0.77 | ROCK2 (0.63) | ROCK2GSK3BDYRK1ACLK2CLK4 | |
| SCHEMBL3665724 | 0.77 | ROCK2 (1.00) | ROCK2GSK3BDYRK1ACLK2CLK4 | |
| SCHEMBL31204217 | 0.76 | ROCK2 (0.65) | ROCK2DYRK1ACLK2CLK4AURKB | |
| SCHEMBL31204281 | 0.75 | ROCK2 (0.74) | ROCK2DYRK1ACLK2CLK4AURKB | |
| SCHEMBL24137563 | 0.74 | CCNC (0.61) | ROCK2GSK3BDYRK1ACLK2CLK4 | |
| SCHEMBL13993855 | 0.73 | CSNK1D (0.64) | ROCK2DYRK1ACLK2CLK4AURKB | |
| SCHEMBL31204260 | 0.73 | DYRK1A (0.64) | ROCK2DYRK1ACLK2CLK4AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | US | claimed |
| WO-2009126635-A1 | 2-AMINO-BENZOTHIAZOLE DERIVATES USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | WO | claimed |
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | US | disclosed |
| WO-2009126635-A1 | 2-AMINO-BENZOTHIAZOLE DERIVATES USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ROCK1, ROCK2, RHOA | ROCK2 2/4885GSK3B 113/4885DYRK1A 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.