Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 5/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 3/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28097592 | 0.77 | LAP3 (0.40) | LAP3METAP1ANPEPERAP1SMPD1 | |
| SCHEMBL183350 | 0.77 | LAP3 (0.40) | LAP3METAP1ANPEPERAP1SMPD1 | |
| SCHEMBL4954493 | 0.77 | LAP3 (0.40) | LAP3METAP1ANPEPERAP1SMPD1 | |
| SCHEMBL5963622 | 0.75 | SMPD1 (0.39) | LAP3METAP1ANPEPERAP1SMPD1 | |
| SCHEMBL5423146 | 0.74 | — | — | |
| SCHEMBL28873876 | 0.72 | SMPD1 (0.34) | SMPD1 | |
| SCHEMBL2475819 | 0.71 | LAP3 (0.38) | LAP3METAP1SMPD1 | |
| SCHEMBL12960884 | 0.71 | LAP3 (0.38) | LAP3METAP1SMPD1 | |
| SCHEMBL63997 | 0.71 | — | — | |
| SCHEMBL13308410 | 0.70 | SLC7A5 (0.46) | LAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040092720-A1 | Polypeptides comprising IL-6 ligand binding receptor domains | THE GOVEMMENT OF THE U.S. A.,AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2004-05-13 | — | — | US | claimed |
| WO-2001016166-A2 | POLYPEPTIDES, COMPRISING IL-6 LIGAND-BINDING RECEPTOR DOMAINS, AND RELATED NUCLEIC ACIDS, ANTIBODIES, COMPOSITIONS, AND METHODS OF USE | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2001-03-08 | — | — | WO | claimed |
| EP-0578745-A1 | PHOSPHORUS CONTAINING COMPOUNDS AS INHIBITORS OF RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-01-19 | — | — | EP | claimed |
| WO-1992017490-A1 | PHOSPHORUS CONTAINING COMPOUNDS AS INHIBITORS OF RETROVIRUSES | THE UPJOHN COMPANY (US) | 1992-10-15 | — | — | WO | claimed |
| US-20090142849-A1 | Stable Oxygen Isotope Labeling of Pre-existing Phosphoryl Groups on Phosphomolecules for Modification-Specific Mass Spectrometry | UNIVERSITY OF CONNECTICUT (US) | 2009-06-04 | — | — | US | disclosed |
| US-7144986-B2 | Polypeptides comprising IL-6 ligand binding receptor domains | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040092720-A1 | Polypeptides comprising IL-6 ligand binding receptor domains | THE GOVEMMENT OF THE U.S. A.,AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2004-05-13 | — | — | US | disclosed |
| US-6664374-B1 | Interleukin-6 (IL-6); use of novel polypeptide capable of inhibiting binding of IL-6 ligand with IL-6 receptor for treatment of conditions resulting from abnormal expression of IL-6 | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES | 2003-12-16 | — | — | US | disclosed |
| WO-2001016166-A2 | POLYPEPTIDES, COMPRISING IL-6 LIGAND-BINDING RECEPTOR DOMAINS, AND RELATED NUCLEIC ACIDS, ANTIBODIES, COMPOSITIONS, AND METHODS OF USE | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2001-03-08 | — | — | WO | disclosed |