Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.78 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290150 | 1.00 | EPHX2 (0.78) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A | |
| SCHEMBL609034 | 0.94 | EPHX2 (0.79) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A | |
| SCHEMBL4960500 | 0.94 | EPHX2 (0.79) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A | |
| SCHEMBL4145741 | 0.88 | HSD11B1 (0.72) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A | |
| SCHEMBL4143730 | 0.87 | EPHX2 (0.78) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A | |
| SCHEMBL4439394 | 0.87 | EPHX2 (0.78) | EPHX2HSD11B1KMT2ATSHRALDH1A1 | |
| SCHEMBL15916980 | 0.86 | EPHX2 (0.60) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A | |
| SCHEMBL15917555 | 0.86 | EPHX2 (0.60) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A | |
| SCHEMBL612161 | 0.86 | EPHX2 (0.66) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A | |
| SCHEMBL4961320 | 0.86 | EPHX2 (0.66) | EPHX2HSD11B1POLBSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060122197-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2006-06-08 | — | — | US | claimed |
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| CN-101080226-A | Amido compounds and their use as pharmaceuticals | INCYTE CORP (US) | 2007-11-28 | — | — | CN | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| US-20060122197-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2006-06-08 | — | — | US | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122197-A1 | Amido compounds and their use as pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | EPHX2 788/4885HSD11B1 1/4885POLB 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.