Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.56 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.56 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CD69 | Q07108 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | IGF2R | P11717 | 1/20 | 0.48 |
| ▸ | B4GALT1 | P15291 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31536873 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL36783651 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL3717192 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL13702251 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL14345965 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL19903782 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL22576748 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL21940522 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL21018974 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 | |
| SCHEMBL15489113 | 1.00 | MAPK1 (0.71) | MAPK1ALDH1A1THRBLGALS8LGALS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357671-B2 | High affinity Siglec ligands | Paulson, James (US) | 2013-01-22 | — | — | US | disclosed |
| US-20090238837-A1 | High Affinity Siglec Ligands | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-09-24 | — | — | US | disclosed |
| EP-1951740-A2 | HIGH AFFINITY SIGLEC LIGANDS | Paulson, James (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056525-A2 | HIGH AFFINITY SIGLEC LIGANDS | PAULSON JAMES (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2006055925-A2 | MICROARRAYS FOR ANALYTE DETECTION | SWISS FEDERAL INSTITUTE OF TECHNOLOGY (CH) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090238837-A1 | High Affinity Siglec Ligands | SIGLEC7, SIGLEC9, FCGR1A | MAPK1 4553/4885ALDH1A1 488/4885THRB 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.