Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971269 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL2127670 | 0.84 | ALDH1A1 (0.44) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL10568010 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL22607754 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL10568015 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL10569720 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL11626141 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL22607753 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL6165925 | 0.83 | ALDH1A1 (0.45) | ALDH1A1HPGDTAAR1EPHX1NPSR1 | |
| SCHEMBL7994480 | 0.82 | ALDH1A1 (0.43) | ALDH1A1HPGDTAAR1EPHX1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325208-A1 | Biosynthesis of Salinosporamide A and Analogs and Methods Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-12-31 | — | — | US | disclosed |
| WO-2008002600-A2 | BIOSYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS AND METHODS THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-01-03 | — | — | WO | disclosed |