Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 3/20 | 0.38 |
| ▸ | PYGM | P11217 | 3/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4279651 | 0.90 | IRAK4 (0.40) | IRAK4IRAK1NPC1RAB9A | |
| SCHEMBL4283174 | 0.87 | MAPT (0.45) | IRAK4IRAK1NPC1RAB9A | |
| SCHEMBL4287650 | 0.84 | IRAK4 (0.36) | IRAK4IRAK1NPC1RAB9AACKR3 | |
| SCHEMBL4281132 | 0.81 | HTT (0.42) | NPC1RAB9A | |
| SCHEMBL4285098 | 0.79 | GRM5 (0.40) | IRAK4IRAK1 | |
| SCHEMBL22236075 | 0.78 | HDAC1 (0.45) | — | |
| SCHEMBL4289295 | 0.77 | RORC (0.45) | IRAK4ACKR3 | |
| SCHEMBL4285703 | 0.77 | MAPT (0.43) | IRAK4IRAK1NPC1RAB9A | |
| SCHEMBL4284040 | 0.75 | POLB (0.46) | NPC1RAB9A | |
| SCHEMBL4285697 | 0.75 | POLB (0.48) | IRAK4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | GSK3B, GSK3A, GSKIP | IRAK4 415/4885IRAK1 148/4885NPC1 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.