Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 11/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285465 | 0.91 | PIK3CG (0.55) | PIK3CGMAPTMEN1KMT2AKDM4E | |
| SCHEMBL10044924 | 0.87 | PIK3CD (0.65) | PIK3CGPIK3CD | |
| SCHEMBL18167155 | 0.85 | SYK (0.47) | PIK3CGMAPT | |
| SCHEMBL10044927 | 0.84 | MAPT (0.55) | PIK3CGMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL18175007 | 0.83 | PIK3CG (0.47) | PIK3CGMAPTKMT2APIK3CD | |
| SCHEMBL18167153 | 0.81 | EGFR (0.45) | PIK3CGMAPTMEN1KMT2AKDM4E | |
| SCHEMBL4296830 | 0.80 | PIK3CG (0.54) | PIK3CGMAPTMEN1KMT2APIK3CD | |
| SCHEMBL4300600 | 0.79 | MAPT (0.54) | PIK3CGMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL15194269 | 0.78 | PIK3CG (0.60) | PIK3CGMAPTPIK3CD | |
| SCHEMBL4288292 | 0.77 | PIK3CG (0.59) | PIK3CGMAPTPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052102-A1 | QUINOXALINE DERIVATES | MERCK PATENT GMBH (DE) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012052420-A1 | METHOD FOR PREPARING SUBSTITUTED N-(3-AMINO-QUINOXALIN-2-YL)-SULFONAMIDES AND THEIR INTERMEDIATES N-(3-CHLORO-QUINOXALIN-2-YL)SULFONAMIDES | MERCK SERONO S.A. GENEVA (CH) | 2012-04-26 | — | — | WO | disclosed |