SCHEMBL4291874

SCHEMBL4291874

CC(C)(C)CC(C)(C)c1ccc(OC(Cl)(Cl)C(=O)O)cc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
SHBG P04278 1/20 0.47
MDH1 P40925 9/20 0.44
MDH2 P40926 9/20 0.44
PPARA Q07869 5/20 0.42
MEN1 O00255 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42
PPARG P37231 3/20 0.41
HIF1A Q16665 1/20 0.38
FABP2 P12104 1/20 0.38
SLC22A12 Q96S37 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10611806 0.84 PPARA (0.58) CYP3A4SMN1; SMN2SHBGMDH1MDH2
SCHEMBL28761267 0.77 SMN1; SMN2 (0.56) CYP3A4SMN1; SMN2SHBGMDH1MDH2
SCHEMBL28497693 0.76 CYP3A4 (0.59) CYP3A4SMN1; SMN2SHBGMDH1MDH2
SCHEMBL13019868 0.76 CYP3A4 (0.58) CYP3A4SMN1; SMN2SHBGMDH1MDH2
SCHEMBL9457427 0.76 CYP3A4 (0.54) CYP3A4SMN1; SMN2SHBGMDH1MDH2
SCHEMBL1064180 0.75 CYP3A4 (0.57) CYP3A4SMN1; SMN2SHBGMDH1MDH2
SCHEMBL3988308 0.74 PPARA (0.47) CYP3A4SMN1; SMN2PPARAMEN1CYP1A2
SCHEMBL6699973 0.74 SMN1; SMN2 (0.70) CYP3A4SMN1; SMN2SHBGMDH1MDH2
SCHEMBL28317536 0.74 SMN1; SMN2 (0.49) CYP3A4SMN1; SMN2SHBGMDH1MDH2
SCHEMBL15239751 0.74 HIF1A (0.55) CYP3A4SMN1; SMN2SHBGMDH1MDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009154697-A2 DISC-1 PATHWAY ACTIVATORS IN THE CONTROL OF NEUROGENESIS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2009-12-23 WO disclosed