Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 11/20 | 0.47 |
| ▸ | ACACA | Q13085 | 8/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | TYK2 | P29597 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3988578 | 0.87 | PRKCQ (0.50) | ACACBACACAVCPDRD2CKS1B | |
| SCHEMBL3986902 | 0.86 | PRKCQ (0.52) | VCPJAK2JAK1TYK2JAK3 | |
| SCHEMBL5281049 | 0.84 | ACACB (0.42) | ACACBACACAVCPDRD2CKS1B | |
| SCHEMBL3984372 | 0.82 | ACACB (0.44) | ACACBACACAVCPDRD2CYP3A4 | |
| SCHEMBL3820652 | 0.80 | PRKCQ (0.51) | ACACBACACAVCPDRD2CKS1B | |
| SCHEMBL3821024 | 0.77 | PRKCQ (0.48) | ACACBACACADRD2CKS1BSKP1 | |
| SCHEMBL13720173 | 0.77 | PRKCQ (0.51) | ACACBACACAVCPDRD2CKS1B | |
| SCHEMBL13794230 | 0.77 | PRKCQ (0.51) | ACACBACACAVCPDRD2CKS1B | |
| SCHEMBL13795088 | 0.75 | PRKCQ (0.52) | ACACBACACADRD2CKS1BSKP1 | |
| SCHEMBL30156977 | 0.75 | ACACB (0.48) | ACACBACACADRD2CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866286-B1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-05-27 | — | — | EP | disclosed |
| EP-1866286-B1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-05-27 | — | — | EP | disclosed |
| US-7468382-B2 | Pyridine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-23 | — | — | US | disclosed |
| US-7468382-B2 | Pyridine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-23 | — | — | US | disclosed |
| EP-1866286-A1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105023-A1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-10-05 | — | — | WO | disclosed |
| US-20060217417-A1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217417-A1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | PRKCQ, PRKCH, PRKCZ | ACACB 1724/4885ACACA 1882/4885VCP 3029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.