Sugi Predict

Sugi Predict / Compounds / SCHEMBL4293087

SCHEMBL4293087

SCHEMBL4293087

CCOC(=O)n1nc(NC(=O)c2ccc(N3CCN(C)CC3)c(N(C)CCOC)c2)c2c1CNC2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 3/20 0.35
▸ WDR5 P61964 4/20 0.34
▸ HTR1D P28221 2/20 0.34
▸ HTR1B P28222 2/20 0.34
▸ HTR2A P28223 2/20 0.34
▸ MAPK14 Q16539 2/20 0.34
▸ FGFR2 P21802 1/20 0.33
▸ MAPT P10636 2/20 0.33
▸ RAF1 P04049 1/20 0.33
▸ BRAF P15056 1/20 0.33
▸ AURKA O14965 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ KDR P35968 1/20 0.33
▸ FLT3 P36888 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ ALOX12 P18054 1/20 0.33
▸ NR4A1 P22736 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4293085 0.99 FGFR1 (0.34) FGFR1WDR5HTR1DHTR1BHTR2A
SCHEMBL4278036 0.85 MAPK14 (0.35) WDR5HTR1DHTR1BHTR2AMAPK14
SCHEMBL15338603 0.83 WDR5 (0.36) FGFR1WDR5HTR1DHTR1BHTR2A
SCHEMBL4285149 0.82 TAAR1 (0.45) RAF1BRAFAURKA
SCHEMBL4279306 0.82 MAPT (0.50) WDR5MAPTLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL4285146 0.82 TAAR1 (0.44) RAF1BRAFAURKA
Hydrochloric Acid SCHEMBL4279298 0.81 MAPT (0.50) WDR5MAPTLMNASMN1; SMN2
SCHEMBL4279263 0.81 IGF1R (0.39) MAPTLMNANPSR1SMN1; SMN2HSD17B10
SCHEMBL5449603 0.81 MEN1 (0.49) MAPTAURKAKDRFLT3ALOX15
Hydrochloric Acid SCHEMBL2927668 0.80 MEN1 (0.48) MAPTAURKAKDRFLT3ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012487-B2 Bicyclo-pyrazoles active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2015-04-21 — — US disclosed
US-9012487-B2 Bicyclo-pyrazoles active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2015-04-21 — — US disclosed
US-9012487-B2 Bicyclo-pyrazoles active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2015-04-21 — — US disclosed
EP-1999131-B1 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2013-10-23 — — EP disclosed
US-20090136513-A1 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L (IT) 2009-05-28 — — US disclosed
US-20090136513-A1 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L (IT) 2009-05-28 — — US disclosed
US-20090136513-A1 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L (IT) 2009-05-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090136513-A1 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS MAP3K19, CDK2, MAP3K1 FGFR1 371/4885WDR5 3189/4885HTR1D 2140/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.