Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4576841 | 0.93 | FDPS (0.57) | FDPSMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL5213944 | 0.87 | TACR2 (0.54) | FDPSMAPTALDH1A1NPSR1LMNA | |
| SCHEMBL9077155 | 0.87 | TACR2 (0.54) | FDPSMAPTALDH1A1NPSR1LMNA | |
| SCHEMBL29721221 | 0.87 | TACR2 (0.54) | FDPSMAPTALDH1A1NPSR1LMNA | |
| SCHEMBL7141110 | 0.85 | FDPS (0.55) | FDPSMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL30467215 | 0.85 | FDPS (0.55) | FDPSMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL9078005 | 0.84 | FDPS (0.72) | FDPSMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL6229249 | 0.84 | FDPS (0.63) | FDPSMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL31331562 | 0.84 | FDPS (0.72) | FDPSMAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL21427194 | 0.84 | FDPS (0.54) | FDPSMAPTALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954815-B1 | PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION | GLYCOFI INC (US) | 2015-02-25 | — | — | EP | disclosed |
| US-8795984-B2 | Production of glycoproteins with reduced O-glycosylation | MERCK SHARP & DOHME CORP. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8501438-B2 | Production of glycoproteins with reduced O-glycosylation | GLYCOFI, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120322101-A1 | PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION | GLYCOFI, INC. (US) | 2012-12-20 | — | — | US | disclosed |
| US-20120237973-A1 | PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION | GLYCOFI, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-8206949-B2 | Production of glycoproteins with reduced O-glycosylation | GLYCOFI, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20090170159-A1 | PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION | GLYCOFI, INC (US) | 2009-07-02 | — | — | US | disclosed |
| EP-1954815-A2 | PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION | Glycofi, Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007061631-A2 | PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION | GLYCOFI, INC (US) | 2007-05-31 | — | — | WO | disclosed |
| EP-1313471-B1 | BENZYLIDENE THIAZOLIDINEDIONES AND THEIR USE AS ANTIMYCOTIC AGENTS | UCB SA (BE) | 2007-04-11 | — | — | EP | disclosed |
| US-7105554-B2 | Benzylidene thiazolidinediones and their use as antimycotic agents | OXFORD GLYCOSCIENCES (UK) LTD. (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20040006112-A1 | Benzylidene thiazolidinediones and their use as antimycotic agents | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-01-08 | — | — | US | disclosed |
| EP-1313471-A1 | BENZYLIDENE THIAZOLIDINEDIONES AND THEIR USE AS ANTIMYCOTIC AGENTS | Oxford GlycoSciences (UK) Limited (GB) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002017915-A1 | BENZYLIDENE THIAZOLIDINEDIONES AND THEIR USE AS ANTIMYCOTIC AGENTS | OXFORD GLYCOSCIENCES (UK) LIMITED (GB) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006112-A1 | Benzylidene thiazolidinediones and their use as antimycotic agents | SLC5A2, OXSR1, SLC5A1 | FDPS 2387/4885MAPT 4658/4885ALDH1A1 2757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.