Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | HTR1D | P28221 | 4/20 | 0.39 |
| ▸ | HTR1B | P28222 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | DDX3X | O00571 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402096 | 0.90 | CYP1A2 (0.46) | HTR1AHTR1DHTR1BCYP1A2DDX3X | |
| SCHEMBL402430 | 0.85 | HTR1A (0.42) | HTR1AHTR1DHTR1BCYP1A2DDX3X | |
| SCHEMBL3210124 | 0.80 | HTR1A (0.45) | HTR1AHTR1DHTR1BDDX3XMAPK10 | |
| SCHEMBL545635 | 0.80 | HTR1A (0.43) | HTR1AHTR1DHTR1BCYP1A2DDX3X | |
| SCHEMBL401393 | 0.80 | CYP1A2 (0.48) | HTR1AHTR1DHTR1BCYP1A2MAPK10 | |
| SCHEMBL401663 | 0.79 | HTR1A (0.42) | HTR1AHTR1DHTR1BDDX3XMAPK10 | |
| SCHEMBL402570 | 0.78 | HRH2 (0.46) | HTR1AHTR1DHTR1BDDX3XHTR7 | |
| SCHEMBL401052 | 0.78 | HTR1A (0.40) | HTR1AHTR1DHTR1BDDX3XMAPK10 | |
| SCHEMBL399090 | 0.76 | HTR1A (0.50) | HTR1ACYP1A2DRD2HTR7DRD3 | |
| SCHEMBL401053 | 0.76 | HRH2 (0.44) | HTR1AHTR1DHTR1BDDX3XDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | claimed |