Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MDH1 | P40925 | 2/20 | 0.58 |
| ▸ | MDH2 | P40926 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31503974 | 0.90 | TRPV1 (0.70) | ALDH1A1HIF1AEPAS1SMN1; SMN2TRPV1 | |
| SCHEMBL4295568 | 0.88 | HIF1A (0.73) | ALDH1A1HIF1AEPAS1SMN1; SMN2TRPV1 | |
| SCHEMBL5426307 | 0.86 | MAPT (0.74) | ALDH1A1SMN1; SMN2CA1CA2MAPT | |
| SCHEMBL4296995 | 0.85 | HIF1A (0.80) | ALDH1A1HIF1AEPAS1SMN1; SMN2MAPT | |
| SCHEMBL27090192 | 0.85 | TRPV1 (0.64) | ALDH1A1HIF1AEPAS1SMN1; SMN2TRPV1 | |
| SCHEMBL5431174 | 0.85 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL21588706 | 0.85 | MEN1 (0.64) | ALDH1A1HIF1AEPAS1TRPV1MAPT | |
| SCHEMBL28579207 | 0.84 | MEN1 (0.66) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL5424498 | 0.84 | KMT2A (0.67) | ALDH1A1SMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL2833331 | 0.83 | MAPT (0.75) | ALDH1A1SMN1; SMN2MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394799-B2 | Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2013-03-12 | — | — | US | disclosed |
| US-20090306078-A1 | COMPOUNDS THAT INHIBIT HIF-1 ACTIVITY, THE METHOD FOR PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM AS AN EFFECTIVE COMPONENT | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306078-A1 | COMPOUNDS THAT INHIBIT HIF-1 ACTIVITY, THE METHOD FOR PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM AS AN EFFECTIVE COMPONENT | HIF1AN, HIF1A, VHL | ALDH1A1 499/4885HIF1A 2/4885EPAS1 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.