Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11880546 | 0.85 | NPC1 (0.46) | ACLYNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL1221632 | 0.85 | CYP19A1 (0.50) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL6074414 | 0.84 | SLC40A1 (0.51) | MCL1BCL2A1ACLYNPC1HPGD | |
| SCHEMBL7112677 | 0.83 | AR (0.49) | ACLYNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL7107169 | 0.83 | NPC1 (0.46) | ACLYNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL7111802 | 0.81 | SMN1; SMN2 (0.47) | ACLYNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL7109250 | 0.81 | NPC1 (0.48) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL10451702 | 0.80 | NPC1 (0.50) | NPC1HPGDRAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL8607319 | 0.80 | CYP19A1 (0.56) | NPC1HPGDRAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL7109049 | 0.80 | EGFR (0.45) | ACLYNPC1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035004-A1 | PHENYL SUBSTITUTED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS POSSESSING BETA AGONIST ACTIVITY | Parion Sciences, Inc. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146869-A1 | PHENYL SUBSTITUTED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS POSSESSING BETA AGONIST ACTIVITY | PARION SCIENCES, INC. (US) | 2007-12-21 | — | — | WO | disclosed |