Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 6/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4307622 | 0.91 | MAP4K4 (0.40) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL8989840 | 0.89 | TRPV3 (0.41) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL4301613 | 0.88 | MAPK14 (0.41) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL4298655 | 0.82 | MAP4K4 (0.48) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL4299246 | 0.81 | MAP4K4 (0.53) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL4299247 | 0.81 | MAP4K4 (0.53) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL4304649 | 0.81 | MAP4K4 (0.53) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL4298116 | 0.79 | MAP4K4 (0.46) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL4303985 | 0.79 | EGFR (0.51) | MAPK9MAP4K4CSNK1DMINK1PRKD2 | |
| SCHEMBL4296181 | 0.79 | MAP4K4 (0.53) | MAPK9MAP4K4CSNK1DMINK1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188083-B2 | Triazolopyridazines | ABBOTT LABORATORIES (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090270402-A1 | Novel triazolopyridazines | ABBVIE INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270402-A1 | Novel triazolopyridazines | MAP3K5, MAP3K1, MAP3K2 | MAPK9 101/4885MAP4K4 24/4885CSNK1D 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.