Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenoxylate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 1.00 |
| ▸ | KCNA3 | P22001 | 5/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenoxylate SCHEMBL28385054 | 0.99 | OPRM1 (0.98) | OPRM1KCNA3OPRD1OPRK1SLC22A1 | |
| Diphenoxylate SCHEMBL20595320 | 0.99 | OPRM1 (0.98) | OPRM1KCNA3OPRD1OPRK1SLC22A1 | |
| Diphenoxylate SCHEMBL28374697 | 0.99 | OPRM1 (0.98) | OPRM1KCNA3OPRD1OPRK1SLC22A1 | |
| Diphenoxylate SCHEMBL28596518 | 0.99 | OPRM1 (0.98) | OPRM1KCNA3OPRD1OPRK1SLC22A1 | |
| Diphenoxylate SCHEMBL42124 | 0.99 | OPRM1 (0.98) | OPRM1KCNA3OPRD1OPRK1SLC22A1 | |
| Diphenoxylate SCHEMBL3083175 | 0.97 | OPRM1 (0.94) | OPRM1KCNA3OPRD1OPRK1SLC22A1 | |
| Diphenoxylate SCHEMBL8160138 | 0.97 | OPRM1 (0.94) | OPRM1KCNA3OPRD1OPRK1SLC22A1 | |
| Diphenoxylate SCHEMBL29019114 | 0.92 | OPRM1 (0.84) | OPRM1KCNA3OPRD1OPRK1SLC22A1 | |
| Butoxylate SCHEMBL23852174 | 0.90 | KCNA3 (0.82) | OPRM1KCNA3OPRD1OPRK1 | |
| Butoxylate SCHEMBL241324 | 0.90 | KCNA3 (0.82) | OPRM1KCNA3OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 16668 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-12440489-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2025-10-14 | — | — | US | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| US-20250235641-A1 | DEVICE TO DELIVER A PREDETERMINED AMOUNT OF A SUBSTANCE TO A NATURAL ORIFICE OF THE BODY | APTARGROUP INC. (US) | 2025-07-24 | — | — | US | claimed |
| US-20250228771-A1 | ALKALINE INTRAORAL PRODUCTS | EMPLICURE AB (publ) (SE) | 2025-07-17 | — | — | US | claimed |
| US-20250191770-A1 | COMPUTERIZED DECISION SUPPORT TOOL AND MEDICAL DEVICE FOR RESPIRATORY CONDITION MONITORING AND CARE | PFIZER INC. (US) | 2025-06-12 | — | — | US | claimed |
| EP-4565202-A1 | ALKALINE INTRAORAL PRODUCTS | EMPLICURE AB (publ) (SE) | 2025-06-11 | — | — | EP | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| US-12296043-B2 | Liquisoft capsules | PATHEON SOFTGELS INC. (US) | 2025-05-13 | — | — | US | claimed |
| US-20250144025-A1 | ANTI-ABUSE GELLED PHARMACEUTICAL COMPOSITIONS | VITUX GROUP AS (NO) | 2025-05-08 | — | — | US | claimed |
| EP-0531421-A1 | CONTRAST MEDIA FOR ULTRASONIC IMAGING | IMARX PHARMACEUTICAL CORP. (US) | 1993-03-17 | — | — | EP | claimed |
| WO-1992000082-A1 | ANTIDIARRHEAL COMPOSITIONS AND METHODS | THE PROCTER & GAMBLE COMPANY (US) | 1992-01-09 | — | — | WO | claimed |
| EP-0465234-A1 | Pharmaceutical compositions and methods for alleviating gastrointestinal distress symptoms induced by nonsteroidal anti-inflammatory drugs | McNEIL-PPC, INC. (US) | 1992-01-08 | — | — | EP | claimed |
| US-5074842-A | Scheduled bowel management system | CLAYTON RALPH S (US) | 1991-12-24 | — | — | US | claimed |
| WO-1991018612-A1 | CONTRAST MEDIA FOR ULTRASONIC IMAGING | UNGER EVAN C (US) | 1991-12-12 | — | — | WO | claimed |
| EP-0428296-A2 | Pharmaceutical compositions for treating gastrointestinal distress | McNEIL-PPC, INC. (US) | 1991-05-22 | — | — | EP | claimed |
| US-4952402-A | EDIBLE TASTE-MASKED DRUGS; MICROMATRIX ACTIVE MATERIAL COATED WITH NONTOXIC POLYMER; LIQUIDS; TABLETS | ELAN CORPORATION, P.L.C. (IE) | 1990-08-28 | — | — | US | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |
| US-4086234-A | Process for the preparation of tertiary amines | G. D. SEARLE & CO. (US) | 1978-04-25 | — | — | US | claimed |