Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.47 |
| ▸ | TUBB | P07437 | 7/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310018 | 0.83 | SLC2A1 (0.41) | KDREGFRPDGFRBTUBB3TUBB4A | |
| SCHEMBL20111051 | 0.83 | KDR (0.47) | KDREGFRPDGFRBTUBB3TUBB4A | |
| SCHEMBL4731660 | 0.81 | KCNH2 (0.40) | KDRDHFRPDGFRA | |
| SCHEMBL5394102 | 0.80 | CHKA (0.44) | KDREGFRPDGFRBDHFR | |
| SCHEMBL3634677 | 0.79 | EPHB4 (0.51) | KDR | |
| SCHEMBL17266579 | 0.78 | KCNH2 (0.42) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL4308082 | 0.78 | KDR (0.40) | KDREGFRPDGFRBTUBB3TUBB4A | |
| SCHEMBL4297825 | 0.78 | CTSK (0.40) | KDREGFRPDGFRBTUBB3TUBB4A | |
| SCHEMBL4433094 | 0.77 | FGFR1 (0.39) | KDRDHFR | |
| SCHEMBL4300255 | 0.77 | MEN1 (0.53) | KDREGFRPDGFRBTUBB3TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | claimed |
| WO-2008061112-A9 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS INC (US) | 2008-09-18 | — | — | WO | claimed |
| WO-2008061112-A2 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INC. (US) | 2008-05-22 | — | — | WO | claimed |
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2008061112-A9 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS INC (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008061112-A2 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MYRIAD GENETICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090280133-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | MKI67, CCNI, CCNA1 | KDR 1693/4885EGFR 288/4885PDGFRB 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.