Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 7/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401714 | 0.84 | ACKR3 (0.49) | ACKR3HTR1AHTR1DHTR1BALDH1A1 | |
| SCHEMBL402629 | 0.78 | HTR1A (0.54) | ACKR3HTR1AALDH1A1FAAHKDM4E | |
| SCHEMBL3734785 | 0.77 | NAMPT (0.47) | — | |
| SCHEMBL5946682 | 0.76 | ICAM1 (0.41) | ACKR3HTR1AHTR1DHTR1BALDH1A1 | |
| SCHEMBL401272 | 0.76 | HTR1A (0.53) | HTR1AHTR1DHTR1B | |
| SCHEMBL3736252 | 0.74 | NAMPT (0.42) | ACKR3ALDH1A1KDM4EICAM1 | |
| SCHEMBL3742162 | 0.74 | NAMPT (0.42) | ACKR3ALDH1A1KDM4EICAM1 | |
| SCHEMBL402086 | 0.74 | ACKR3 (0.51) | ACKR3HTR1AHTR1DHTR1BALDH1A1 | |
| SCHEMBL3731787 | 0.72 | NAMPT (0.45) | ICAM1SMN1; SMN2 | |
| SCHEMBL401393 | 0.72 | CYP1A2 (0.48) | HTR1AHTR1DHTR1BALDH1A1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |