Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934348 | 0.89 | FGFR1 (0.40) | FGFR1KDRFGFR2FGFR3OPRL1 | |
| SCHEMBL4129225 | 0.88 | SYK (0.44) | FGFR1KDRFGFR2FGFR3OPRL1 | |
| SCHEMBL4124997 | 0.88 | FGFR1 (0.41) | FGFR1KDRFGFR2FGFR3PDGFRB | |
| SCHEMBL3932241 | 0.86 | FGFR1 (0.42) | FGFR1KDRFGFR2FGFR3OPRL1 | |
| Trifluoroacetic Acid SCHEMBL4133711 | 0.85 | FGFR1 (0.38) | FGFR1KDRFGFR2FGFR3OPRL1 | |
| SCHEMBL18833424 | 0.84 | FGFR1 (0.46) | FGFR1KDRFGFR2FGFR3CSF1R | |
| Trifluoroacetic Acid SCHEMBL4138498 | 0.83 | SYK (0.41) | FGFR1KDRFGFR2FGFR3OPRL1 | |
| SCHEMBL4129282 | 0.83 | FGFR1 (0.43) | FGFR1KDRFGFR2FGFR3CSF1R | |
| SCHEMBL3928874 | 0.83 | SYK (0.46) | FGFR1KDRFGFR2FGFR3CSF1R | |
| SCHEMBL18833148 | 0.83 | FGFR1 (0.42) | FGFR1KDRFGFR2FGFR3OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041119-A1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | Aventis Pharma S.A. (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008003857-A1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2008-01-10 | — | — | WO | disclosed |