Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 12/20 | 0.35 |
| ▸ | CSF1R | P07333 | 7/20 | 0.35 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | SIK2 | Q9H0K1 | 4/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 4/20 | 0.33 |
| ▸ | SIK1 | P57059 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376265 | 0.82 | IRAK4 (0.34) | FLT3KDRCSF1RSIK2 | |
| SCHEMBL429603 | 0.80 | KDR (0.39) | FLT3KDRCSF1RSIK2SIK3 | |
| SCHEMBL1923038 | 0.80 | KDR (0.39) | FLT3KDRCSF1RSIK2SIK3 | |
| SCHEMBL386046 | 0.75 | FLT3 (0.51) | FLT3KDRCSF1RKIT | |
| SCHEMBL386045 | 0.75 | FLT3 (0.51) | FLT3KDRCSF1RKIT | |
| SCHEMBL10238377 | 0.75 | FLT3 (0.52) | FLT3KDRCSF1RKIT | |
| SCHEMBL26358257 | 0.72 | FLT3 (0.43) | FLT3KDRCSF1RKIT | |
| SCHEMBL26358255 | 0.72 | FLT3 (0.43) | FLT3KDRCSF1RKIT | |
| SCHEMBL376071 | 0.71 | MAPK8 (0.37) | — | |
| SCHEMBL376184 | 0.70 | EIF2AK4 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328890-B1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |