Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115222 | 0.97 | TSHR (0.45) | TSHRHRH3PHGDHMGLLGPR119 | |
| SCHEMBL987309 | 0.94 | TSHR (0.47) | TSHRHRH3PHGDHMGLLGPR119 | |
| SCHEMBL2114280 | 0.93 | TSHR (0.41) | TSHRHRH3PHGDHMGLLGPR119 | |
| SCHEMBL985944 | 0.92 | PHGDH (0.47) | TSHRHRH3PHGDHMGLLSLC18A3 | |
| SCHEMBL2117627 | 0.89 | HRH3 (0.37) | TSHRHRH3PHGDHMGLLGPR119 | |
| SCHEMBL2118576 | 0.89 | HRH3 (0.38) | HRH3PHGDHMGLLGPR119SLC18A3 | |
| SCHEMBL446116 | 0.88 | GPR119 (0.42) | TSHRHRH3PHGDHMGLLGPR119 | |
| SCHEMBL2117149 | 0.87 | TSHR (0.48) | TSHRHRH3PHGDHMGLLGPR119 | |
| SCHEMBL2114984 | 0.86 | GPR119 (0.40) | TSHRHRH3PHGDHMGLLGPR119 | |
| Hydrochloric Acid SCHEMBL28302418 | 0.86 | GPR119 (0.40) | TSHRHRH3PHGDHMGLLGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106573925-B | Process for large scale production of N- [4- (1-cyclobutylpiperidin-4-yloxy) phenyl ] -2- (morpholin-4-yl) acetamide dihydrochloride | 苏文生命科学有限公司 | 2020-04-10 | — | — | CN | claimed |
| EP-3180334-B1 | PROCESS FOR LARGE SCALE PRODUCTION OF N-[4-(1- CYCLOBUTYL PIPERIDIN-4-YLOXY) PHENYL]-2-(MORPHOLIN-4-YL) ACET AMIDE DIHYDROCHLORIDE | SUVEN LIFE SCIENCES LTD (IN) | 2018-09-26 | — | — | EP | claimed |
| US-9802896-B2 | Process for large scale production of N-[4-(1-cyclobutyl piperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide dihydrochloride | SUVEN LIFE SCIENCES LIMITED (IN) | 2017-10-31 | — | — | US | claimed |
| US-20170260135-A1 | PROCESS FOR LARGE SCALE PRODUCTION OF N-[4-(1-CYCLOBUTYL PIPERIDIN-4-YLOXY) PHENYL]-2-(MORPHOLIN-4-YL) ACETAMIDE DIHYDROCHLORIDE | SUVEN LIFE SCIENCES LIMITED (IN) | 2017-09-14 | — | — | US | claimed |
| EP-3180334-A1 | PROCESS FOR LARGE SCALE PRODUCTION OF N-[4-(1- CYCLOBUTYL PIPERIDIN-4-YLOXY) PHENYL]-2-(MORPHOLIN-4-YL) ACET AMIDE DIHYDROCHLORIDE | Suven Life Sciences Limited (IN) | 2017-06-21 | — | — | EP | claimed |
| WO-2016027275-A1 | PROCESS FOR LARGE SCALE PRODUCTION OF N-[4-(1- CYCLOBUTYL PIPERIDIN-4-YLOXY) PHENYL]-2-(MORPHOLIN-4-YL) ACET AMIDE DIHYDROCHLORIDE | SUVEN LIFE SCIENCES LIMITED (IN) | 2016-02-25 | — | — | WO | claimed |
| US-20090306375-A1 | Process for production of 4(3H)-quinazolinone derivative | MSD K.K. (JP) | 2009-12-10 | — | — | US | claimed |
| EP-1900733-A1 | PROCESS FOR PRODUCTION OF 4(3H)-QUINAZOLINONE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-03-19 | — | — | EP | claimed |
| US-12172980-B2 | Compounds as neuronal histamine receptor-3 antagonists and uses thereof | XWPharma Ltd. (KY) | 2024-12-24 | — | — | US | disclosed |
| EP-3856719-B1 | COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF | XWPHARMA LTD (KY) | 2023-06-07 | — | — | EP | disclosed |
| US-20230142119-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-05-11 | — | — | US | disclosed |
| US-20220380339-A1 | COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF | XWPharma Ltd. (KY) | 2022-12-01 | — | — | US | disclosed |
| US-20220380339-A1 | COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF | XWPharma Ltd. (KY) | 2022-12-01 | — | — | US | disclosed |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-09-29 | — | — | US | disclosed |
| EP-1892241-A1 | NOVEL PIPERIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-02-27 | — | — | EP | disclosed |
| US-20070254892-A1 | Dihydropyrazolopyrimidinone derivatives | MSD K.K. (JP) | 2007-11-01 | — | — | US | disclosed |
| CN-1950351-A | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as h3 ligands | WARNER LAMBERT CO (US) | 2007-04-18 | — | — | CN | disclosed |
| EP-1747210-A1 | 3- OR 4-MONOSUBSTITUTED PHENOL AND THIOPHENOL DERIVATIVES USEFUL AS H3 LIGANDS | Warner-Lambert Company LLC (US) | 2007-01-31 | — | — | EP | disclosed |
| US-20050267095-A1 | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands | ZIARCO INC. | 2005-12-01 | — | — | US | disclosed |
| WO-2005108384-A1 | 3- OR 4-MONOSUBSTITUTED PHENOL AND THIOPHENOL DERIVATIVES USEFUL AS H3 LIGANDS | WARNER-LAMBERT COMPANY LLC (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142119-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | TSHR 1860/4885HRH3 2951/4885PHGDH 1354/4885 |
| US-20220380339-A1 | COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF | HRH3, HRH4, HRH2 | TSHR 242/4885HRH3 1/4885PHGDH 1176/4885 |
| US-12172980-B2 | Compounds as neuronal histamine receptor-3 antagonists and uses thereof | HRH3, HRH4, HRH2 | TSHR 338/4885HRH3 1/4885PHGDH 838/4885 |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | TSHR 1860/4885HRH3 2951/4885PHGDH 1354/4885 |
| US-20170260135-A1 | PROCESS FOR LARGE SCALE PRODUCTION OF N-[4-(1-CYCLOBUTYL PIPERIDIN-4-YLOXY) PHENYL]-2-(MORPHOLIN-4-YL) ACETAMIDE DIHYDROCHLORIDE | RIMKLA, QPCT, EIF4H | TSHR 4135/4885HRH3 3192/4885PHGDH 368/4885 |
| US-20070254892-A1 | Dihydropyrazolopyrimidinone derivatives | WEE1, WEE2, GRK3 | TSHR 1616/4885HRH3 622/4885PHGDH 2851/4885 |
| US-20050267095-A1 | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands | HRH4, HRH3, TLR4 | TSHR 1084/4885HRH3 2/4885PHGDH 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.