Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.68 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.45 |
| ▸ | CLK1 | P49759 | 5/20 | 0.45 |
| ▸ | CLK2 | P49760 | 5/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.45 |
| ▸ | CLK3 | P49761 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292438 | 0.88 | NCOA3 (0.59) | NCOA3HIPK2CHEK1DYRK1ACLK1 | |
| SCHEMBL4300946 | 0.82 | NCOA3 (0.68) | NCOA3HIPK2CHEK1DYRK1ACLK1 | |
| SCHEMBL13659546 | 0.81 | NCOA3 (1.00) | NCOA3HIPK2DYRK1ACLK1CLK2 | |
| SCHEMBL4292177 | 0.78 | CSNK2A1 (0.43) | NCOA3HIPK2CHEK1DYRK1ACLK1 | |
| SCHEMBL13659615 | 0.76 | NCOA3 (0.40) | NCOA3HIPK2DYRK1ACLK1CLK2 | |
| SCHEMBL4294738 | 0.76 | NCOA3 (0.40) | NCOA3HIPK2DYRK1ACLK1CLK2 | |
| SCHEMBL13659628 | 0.76 | CHEK1 (0.52) | NCOA3HIPK2CHEK1DYRK1ACLK1 | |
| SCHEMBL28455526 | 0.75 | HIPK2 (0.53) | NCOA3HIPK2DYRK1ACLK1CLK4 | |
| SCHEMBL4296233 | 0.73 | CHEK1 (0.47) | NCOA3HIPK2CHEK1HTTHASPIN | |
| SCHEMBL4297677 | 0.73 | CCNT1 (0.40) | NCOA3HIPK2HTTCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, CDKN1A | NCOA3 858/4885HIPK2 116/4885CHEK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.