Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.48 |
| ▸ | CLK1 | P49759 | 4/20 | 0.48 |
| ▸ | CLK2 | P49760 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.48 |
| ▸ | CLK3 | P49761 | 3/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297665 | 0.82 | NCOA3 (0.68) | NCOA3DYRK1ACDK5CDK5R1CLK1 | |
| SCHEMBL13659546 | 0.81 | NCOA3 (1.00) | NCOA3DYRK1ACDK5CDK5R1CLK1 | |
| SCHEMBL13659605 | 0.76 | NCOA3 (0.40) | NCOA3DYRK1ACDK5CDK5R1CLK1 | |
| SCHEMBL4290110 | 0.76 | CHEK1 (0.52) | NCOA3DYRK1ACDK5CDK5R1CLK1 | |
| SCHEMBL4298982 | 0.75 | CHUK (0.49) | NCOA3DYRK1ACLK1HIPK2HTT | |
| SCHEMBL4295258 | 0.73 | KDM4E (0.41) | NCOA3DYRK1AHIPK2HTTHASPIN | |
| SCHEMBL4296237 | 0.73 | CCNT1 (0.40) | NCOA3HIPK2HTTCCNT1CDK9 | |
| SCHEMBL11495903 | 0.72 | NCOA3 (0.54) | NCOA3DYRK1ACDK5CDK5R1CLK1 | |
| SCHEMBL6121563 | 0.72 | CHEK1 (0.51) | NCOA3DYRK1AHIPK2CHEK1PTGES | |
| SCHEMBL4294298 | 0.72 | KDM4E (0.51) | HIPK2KMT2AMEN1HTTPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, CDKN1A | NCOA3 858/4885DYRK1A 762/4885CDK5 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.