Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.43 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4309478 | 0.88 | NR1H4 (0.49) | NR1H4ABCG2ABCB1 | |
| SCHEMBL4311157 | 0.87 | NR1H4 (0.49) | NR1H4ABCG2ESR1PGRABCB1 | |
| SCHEMBL274613 | 0.87 | NR1H4 (0.57) | NR1H4ALDH1A1ABCG2 | |
| SCHEMBL4306792 | 0.83 | HPGD (0.45) | ALDH1A1 | |
| SCHEMBL4302795 | 0.79 | ABCG2 (0.43) | NR1H4ABCG2ESR1PGRABCB1 | |
| SCHEMBL278968 | 0.78 | NR1H4 (0.69) | NR1H4ABCG2ABCB1 | |
| SCHEMBL274734 | 0.77 | NR1H4 (0.56) | NR1H4ABCG2ABCB1 | |
| SCHEMBL4300714 | 0.76 | CYP19A1 (0.45) | ALDH1A1ABCG2ABCB1 | |
| SCHEMBL687916 | 0.76 | NR1H4 (0.50) | NR1H4ABCG2ESR1ABCB1 | |
| SCHEMBL29880554 | 0.76 | NR1H4 (0.50) | NR1H4ABCG2ESR1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595311-B2 | Modulating active of receptors; therapy prevention of disease such aas symthrome X, antidiabetic agents, insulin resistance, hypoglycemic agents | EXELIXIS, INC. (US) | 2009-09-29 | — | — | US | claimed |