Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299261 | 0.88 | NR1H4 (0.47) | NR1H4ABCB1ABCG2 | |
| SCHEMBL274734 | 0.88 | NR1H4 (0.56) | NR1H4ABCB1ABCG2DRD2DRD3 | |
| SCHEMBL4311157 | 0.84 | NR1H4 (0.49) | NR1H4ABCB1ABCG2 | |
| SCHEMBL4306792 | 0.81 | HPGD (0.45) | MEN1KMT2AKDM4ELMNA | |
| SCHEMBL273929 | 0.78 | NR1H4 (0.61) | NR1H4ABCB1ABCG2 | |
| SCHEMBL272997 | 0.78 | NR1H4 (0.61) | NR1H4ABCB1ABCG2KDM4E | |
| SCHEMBL278968 | 0.78 | NR1H4 (0.69) | NR1H4ABCB1ABCG2KDM4E | |
| SCHEMBL274613 | 0.78 | NR1H4 (0.57) | NR1H4ABCG2KDM4E | |
| SCHEMBL275430 | 0.78 | NR1H4 (0.57) | NR1H4ABCB1ABCG2 | |
| SCHEMBL4302795 | 0.77 | ABCG2 (0.43) | NR1H4ABCB1ABCG2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595311-B2 | Modulating active of receptors; therapy prevention of disease such aas symthrome X, antidiabetic agents, insulin resistance, hypoglycemic agents | EXELIXIS, INC. (US) | 2009-09-29 | — | — | US | claimed |