SCHEMBL4299897

SCHEMBL4299897

CS(=O)(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1I

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 18/20 0.67
EPHX1 P07099 15/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3213643 0.81 EPHX2 (1.00) EPHX2EPHX1
SCHEMBL13651413 0.77 EPHX2 (0.74) EPHX2EPHX1
SCHEMBL4009551 0.75 EPHX1 (0.57) EPHX2EPHX1
SCHEMBL4449239 0.75 EPHX2 (0.74) EPHX2EPHX1
SCHEMBL4011987 0.74 EPHX2 (0.73) EPHX2EPHX1
SCHEMBL4016889 0.72 EPHX2 (0.74) EPHX2EPHX1
Ar9281 SCHEMBL654229 0.72 EPHX2 (1.00) EPHX2EPHX1
Ar9281 SCHEMBL18464997 0.72 EPHX2 (1.00) EPHX2EPHX1
SCHEMBL3955571 0.72 EPHX2 (0.67) EPHX2EPHX1
SCHEMBL15262678 0.72 EPHX2 (0.86) EPHX2EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009129501-A1 USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF SMOOTH MUSCLE DISORDERS ARETE THERAPEUTICS, INC. (US) 2009-10-22 WO disclosed