SCHEMBL4449239

SCHEMBL4449239

O=C(NC1CCN(S(=O)(=O)CI)CC1)NC12CC3CC(CC(C3)C1)C2

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 18/20 0.74
EPHX1 P07099 16/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3213643 0.85 EPHX2 (1.00) EPHX2EPHX1
SCHEMBL4566098 0.84 EPHX2 (0.66) EPHX2EPHX1
SCHEMBL4013323 0.84 EPHX2 (0.66) EPHX2EPHX1
SCHEMBL4015325 0.80 EPHX2 (0.69) EPHX2EPHX1
SCHEMBL4016889 0.80 EPHX2 (0.74) EPHX2EPHX1
SCHEMBL27799472 0.79 EPHX2 (0.63) EPHX2EPHX1
SCHEMBL3717275 0.79 EPHX2 (0.76) EPHX2EPHX1
SCHEMBL15262678 0.77 EPHX2 (0.86) EPHX2EPHX1
SCHEMBL13651413 0.76 EPHX2 (0.74) EPHX2EPHX1
SCHEMBL13651541 0.76 EPHX2 (0.78) EPHX2EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2124917-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS Arete Therapeutics, Inc. (US) 2009-12-02 EP disclosed
WO-2008094869-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS ARETE THERAPEUTICS, INC. (US) 2008-08-07 WO disclosed