Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421384 | 0.88 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2C19CLEC4MKMT2A | |
| SCHEMBL6284285 | 0.84 | CYP1A2 (0.62) | CYP1A2CYP3A4CYP2C19CLEC4MKMT2A | |
| SCHEMBL4301614 | 0.82 | CSNK2A1 (0.56) | CYP1A2CYP3A4CYP2C19KMT2AMEN1 | |
| SCHEMBL7308147 | 0.81 | CYP1A2 (0.76) | CYP1A2CYP3A4CYP2C19CLEC4MKMT2A | |
| SCHEMBL11641095 | 0.80 | CYP1A2 (0.63) | CYP1A2CYP3A4CYP2C19CLEC4MKMT2A | |
| SCHEMBL11200159 | 0.79 | CYP1A2 (0.62) | CYP1A2CYP3A4CYP2C19CLEC4MKMT2A | |
| SCHEMBL2021288 | 0.77 | MEN1 (0.77) | CYP1A2CYP3A4CYP2C19CLEC4MKMT2A | |
| SCHEMBL19644386 | 0.77 | NR4A2 (0.54) | KDM4EMAPTALDH1A1HPGDTP53 | |
| SCHEMBL2805448 | 0.76 | CLEC4M (0.67) | CYP1A2CYP3A4CYP2C19CLEC4MKMT2A | |
| SCHEMBL11639094 | 0.76 | CYP1A2 (0.70) | CYP1A2CYP3A4CYP2C19CLEC4MKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270444-A1 | 1,7-Naphthyridines | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| US-20090270444-A1 | 1,7-Naphthyridines | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| US-20090270444-A1 | 1,7-Naphthyridines | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | disclosed |
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | disclosed |
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | disclosed |
| EP-1866305-A1 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006097340-A1 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-09-21 | — | — | WO | disclosed |
| WO-2006097340-A1 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | PDE4A, PDE3B, PDE4B | CYP1A2 88/4885CYP3A4 31/4885CYP2C19 135/4885 |
| US-20090270444-A1 | 1,7-Naphthyridines | CYP2F1, CYP2S1, CYP1A1 | CYP1A2 11/4885CYP3A4 24/4885CYP2C19 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.