Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | TOP2A | P11388 | 4/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300605 | 1.00 | ADRB2 (0.44) | ADRB2KCNH2TOP2ATOP2BKDM4E | |
| SCHEMBL4298551 | 0.88 | ADRB2 (0.46) | ADRB2KCNH2TOP2ATOP2BKDM4E | |
| SCHEMBL4296299 | 0.82 | KCNH2 (0.51) | KCNH2TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL4296294 | 0.82 | KCNH2 (0.51) | KCNH2TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL4304490 | 0.78 | KDM4E (0.54) | KCNH2TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL4302279 | 0.78 | KDM4E (0.54) | KCNH2TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL4304485 | 0.78 | KDM4E (0.54) | KCNH2TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL30944930 | 0.74 | ADRB2 (0.56) | ADRB2KCNH2TOP2ATOP2BKDM4E | |
| SCHEMBL7011678 | 0.74 | ADRB2 (0.56) | ADRB2KCNH2TOP2ATOP2BKDM4E | |
| SCHEMBL29391687 | 0.74 | ADRB2 (0.61) | ADRB2KCNH2TOP2ATOP2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270379-A1 | QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270379-A1 | QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | NQO2, QARS1, NQO1 | ADRB2 3156/4885KCNH2 3433/4885TOP2A 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.