Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 5/20 | 0.50 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.50 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310170 | 0.87 | KDM4E (0.48) | MAPK13MAPK14BRAFKDRTNNI3K | |
| SCHEMBL13859627 | 0.80 | KCNJ6 (0.69) | KCNJ6KCNJ3KCNJ5BRAFNTRK1 | |
| SCHEMBL1896470 | 0.78 | KDR (0.73) | MAPK14BRAFKDRTNNI3KFLT3 | |
| SCHEMBL2213841 | 0.77 | MAPK14 (0.72) | KCNJ6KCNJ3KCNJ5MAPK13GRM5 | |
| SCHEMBL4307774 | 0.76 | MAPK13 (0.70) | MAPK13MAPK14BRAFMAPK12MAPK11 | |
| SCHEMBL4303949 | 0.74 | KCNJ6 (0.58) | KCNJ6KCNJ3KCNJ5MAPK13MAPK14 | |
| SCHEMBL14133258 | 0.74 | PTPN1 (0.83) | KCNJ6KCNJ3KCNJ5MAPK13GRM5 | |
| SCHEMBL12507772 | 0.73 | KCNJ6 (0.62) | KCNJ6KCNJ3KCNJ5GRM5MAPK14 | |
| SCHEMBL16866510 | 0.73 | MAPK13 (0.83) | MAPK13MAPK14BRAFMAPK12MAPK11 | |
| SCHEMBL4303704 | 0.73 | MAPK14 (0.57) | MAPK13MAPK14BRAFMAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131437-A1 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | CORIUM INTERNATIONAL, INC. (US) | 2009-05-21 | — | — | US | claimed |
| EP-1838700-A2 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | Novartis AG (CH) | 2007-10-03 | — | — | EP | claimed |
| WO-2006072589-A2 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-07-13 | — | — | WO | claimed |
| US-20090131437-A1 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | CORIUM INTERNATIONAL, INC. (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131437-A1 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | UCK2, ULK2, MAP3K1 | KCNJ6 1465/4885KCNJ3 1539/4885KCNJ5 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.