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Sugi Predict / Targets / UCK2

UCK2

Uridine-cytidine kinase 2 · Q9BZX2 · UCK2 on Sugi Atlas →

94 patent compounds predicted against UCK2, 72 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL10817972 SCHEMBL10817972 0.49 4/20
SCHEMBL10818493 SCHEMBL10818493 0.49 4/20
SCHEMBL10817642 SCHEMBL10817642 0.47 4/20
SCHEMBL10815694 SCHEMBL10815694 0.44 4/20
SCHEMBL12713402 SCHEMBL12713402 0.49 3/20
SCHEMBL10817930 SCHEMBL10817930 0.47 3/20
SCHEMBL10818374 SCHEMBL10818374 0.44 3/20
SCHEMBL10839592 SCHEMBL10839592 0.46 2/20
SCHEMBL10818115 SCHEMBL10818115 0.44 2/20
SCHEMBL10812478 SCHEMBL10812478 0.42 2/20
SCHEMBL10816995 SCHEMBL10816995 0.42 2/20
SCHEMBL10817396 SCHEMBL10817396 0.41 2/20
SCHEMBL10815354 SCHEMBL10815354 0.39 2/20
SCHEMBL10817388 SCHEMBL10817388 0.35 2/20
SCHEMBL27897622 SCHEMBL27897622 0.35 2/20
SCHEMBL10840726 SCHEMBL10840726 0.33 2/20
SCHEMBL22042832 SCHEMBL22042832 0.74 1/20
SCHEMBL22042840 SCHEMBL22042840 0.69 1/20
SCHEMBL30489128 SCHEMBL30489128 0.68 1/20
SCHEMBL22042878 SCHEMBL22042878 0.65 1/20

Clinical trials — most relevant to UCK2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity PHASE4UNKNOWN
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
Effect of a Basal/Pre-Meal Insulin Strategy (Detemir/Aspart) on Insulin Secretion and Action in Type 2 Diabetes PHASE4COMPLETED
Chronic Cold Acclimation Stimulates the Browning of Subcutaneous White Adipose in Patients With Type 2 Diabetes Mellitus PHASE4UNKNOWN
Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions PHASE4UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Metformin and Simvastatin Use in Bladder Cancer PHASE2UNKNOWN
Autologous Cytokine Induced Killer Cells (CIK) for Chronic Myeloid Leukemia (CML) Patients on Standard Drug Therapy PHASE2COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
Epirubicin, Docetaxel, and Capecitabine in Treating Women With Stage IIIA or Stage IIIB Breast Cancer PHASE2COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
A Phase I Trial of Continuous Infusion UCN-01 in Patients With Refractory Neoplasms PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Combination of Chemoradiation Therapy and Epitope Peptide Vaccine Therapy in Treating Patients With Esophageal Cancer PHASE1UNKNOWN
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
3'-Deoxy-3'-[18F] Fluorothymidine and Fludeoxyglucose F 18 PET Scans in Evaluating Response to Cetuximab, Cisplatin, and Radiation Therapy in Patients With Advanced Cancer of the Oropharynx, Larynx, or Hypopharynx EARLY_PHASE1COMPLETED
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 EARLY_PHASE1COMPLETED
The Role of Pyruvate Kinase M2 in Growth, Invasion and Drug Resistance in Human Urothelial Carcinoma nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Thermogenic Silencer Regulatory Factors in Humans nanACTIVE_NOT_RECRUITING
Dried Fruit and Postprandial Glycemia Trial nanUNKNOWN
Effect of Age on Glucose and Lipid Metabolism nanCOMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
The Effects of HER2 Receptor Signaling on Human Brown Fat Activity nanRECRUITING
Perfusion-Induced Hyperthermia for Metastatic Carcinoma nanCOMPLETED
Acute Effect of Fructose on Lipid Metabolism and Gender Differences nanCOMPLETED
Normal Serum Adiponectin Levels in Females nanUNKNOWN
Genetic-specific Effects of Fructose on Liver Lipogenesis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a UCK2 binder may also engage these)

ProteinNameSimilarity
Q99PM9 — 1.000 Q99PM9 →
B1H116 — 1.000 B1H116 →
Q7SYM0 — 1.000 Q7SYM0 →
Q9QYG8 — 1.000 Q9QYG8 →
Q7ZV79 — 0.995 Q7ZV79 →
Q6PA79 — 0.995 Q6PA79 →
Q0P5A4 — 0.991 Q0P5A4 →
P52623 — 0.990 P52623 →
Q6GPD9 — 0.989 Q6GPD9 →
Q9HA47 — 0.989 Q9HA47 →
Q66I71 — 0.988 Q66I71 →
Q9VC99 — 0.977 Q9VC99 →
Q4R4K2 — 0.969 Q4R4K2 →
E9Q4Z2 — 0.966 E9Q4Z2 →
Q5T6J7 — 0.966 Q5T6J7 →
O23617 — 0.964 O23617 →
Q8IYB8 — 0.964 Q8IYB8 →
Q920P5 — 0.964 Q920P5 →
Q9Y6K8 — 0.963 Q9Y6K8 →
P27774 — 0.963 P27774 →
Q9WUR9 — 0.963 Q9WUR9 →
Q80YD1 — 0.962 Q80YD1 →
Q0WUI9 — 0.962 Q0WUI9 →
Q8MIR4 — 0.962 Q8MIR4 →
P98192 — 0.962 P98192 →
Q91YL3 — 0.962 Q91YL3 →
Q32PX9 — 0.962 Q32PX9 →
Q80UN9 — 0.961 Q80UN9 →
B4F7E7 — 0.961 B4F7E7 →
Q5VV42 — 0.961 Q5VV42 →